(Puzzle, Rated E) - Picross is a popular Japanese puzzle style that is a bit like Sudoku combined with picture-making. In the case of Picross 3D, you actually "sculpt" a 3D image by correctly figuring out how many blocks in a row need to be chipped away. A perfect combination of logic and creative expression that will engage puzzle veterans and beginners for hours.
(Puzzle/Role-Playing/Adventure, Rated E10+) - Might & Magic: Clash of Heroes was released at the tail-end of 2009, but it'd be a shame not to recommend this excellent blend of puzzle and role-playing. Using strategy, foresight, and a little luck, you match up same-colored troops to take on the enemies' front lines. With a little more luck, you'll save the world.
(Adventure, Rated E10+) - True to Zelda tradition, The Legend of Zelda: Spirit Tracks gives Link a huge world to explore. But enormous swaths of land are no match for a man with a train. When Link isn't conducting, he docks in dungeons, unsheathes his trusty sword, and proceeds with the enemy-slaying and puzzle-solving that's necessary to win the day against evil.
(Educational, Rated E) - Art Academy offers surprisingly complete lessons in sketching, coloring, and painting that make full use of both Nintendo DS screens. With personal one-on-one lessons courtesy of your new instructor, Vince (don't worry, he has both ears), you might find you've always had an eye for art that just needed a little focus.
(Action/Adventure, Rated E10+) - Relive Harry Potter's formative years at Hogwarts -- Lego style. Players experience Harry's first four years at Hogwarts School of Witchcraft and Wizardry, which includes a lot of collecting, exploring, spell-casting, and dark wizard-busting. What, you thought you'd be reciting the multiplication tables?
(Role-Playing, Rated E10+) - Etrian Odyssey III is an advanced role-playing game that tasks you with building almost everything from the ground-up. This includes your characters, your own guild, and even your own map. It's hardly a chore, though, as the game gives you everything you need for you to wholly enjoy the customization process.
(Beat-em-Up, Rated E10+) - Fans of Batman: The Brave and the Bold cartoon will love the game adaptation WayForward put together for the Nintendo DS. At its heart, Brave and the Bold - The Videogame features classic 2D beat-em-up action, but there's a bit of an added bonus. Using the Nintendo DS version, you can join in the fun on the Wii version of the game by playing as the irrepressible Bat-Mite! He's rambunctious, but he means well.